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Oct 7

MInDI-3D: Iterative Deep Learning in 3D for Sparse-view Cone Beam Computed Tomography

We present MInDI-3D (Medical Inversion by Direct Iteration in 3D), the first 3D conditional diffusion-based model for real-world sparse-view Cone Beam Computed Tomography (CBCT) artefact removal, aiming to reduce imaging radiation exposure. A key contribution is extending the "InDI" concept from 2D to a full 3D volumetric approach for medical images, implementing an iterative denoising process that refines the CBCT volume directly from sparse-view input. A further contribution is the generation of a large pseudo-CBCT dataset (16,182) from chest CT volumes of the CT-RATE public dataset to robustly train MInDI-3D. We performed a comprehensive evaluation, including quantitative metrics, scalability analysis, generalisation tests, and a clinical assessment by 11 clinicians. Our results show MInDI-3D's effectiveness, achieving a 12.96 (6.10) dB PSNR gain over uncorrected scans with only 50 projections on the CT-RATE pseudo-CBCT (independent real-world) test set and enabling an 8x reduction in imaging radiation exposure. We demonstrate its scalability by showing that performance improves with more training data. Importantly, MInDI-3D matches the performance of a 3D U-Net on real-world scans from 16 cancer patients across distortion and task-based metrics. It also generalises to new CBCT scanner geometries. Clinicians rated our model as sufficient for patient positioning across all anatomical sites and found it preserved lung tumour boundaries well.

  • 10 authors
·
Aug 13, 2025

Refiner: Restructure Retrieval Content Efficiently to Advance Question-Answering Capabilities

Large Language Models (LLMs) are limited by their parametric knowledge, leading to hallucinations in knowledge-extensive tasks. To address this, Retrieval-Augmented Generation (RAG) incorporates external document chunks to expand LLM knowledge. Furthermore, compressing information from document chunks through extraction or summarization can improve LLM performance. Nonetheless, LLMs still struggle to notice and utilize scattered key information, a problem known as the "lost-in-the-middle" syndrome. Therefore, we typically need to restructure the content for LLM to recognize the key information. We propose Refiner, an end-to-end extract-and-restructure paradigm that operates in the post-retrieval process of RAG. Refiner leverages a single decoder-only LLM to adaptively extract query-relevant contents verbatim along with the necessary context, and section them based on their interconnectedness, thereby highlights information distinction, and aligns downstream LLMs with the original context effectively. Experiments show that a trained Refiner (with 7B parameters) exhibits significant gain to downstream LLM in improving answer accuracy, and outperforms other state-of-the-art advanced RAG and concurrent compressing approaches in various single-hop and multi-hop QA tasks. Notably, Refiner achieves a 80.5% tokens reduction and a 1.6-7.0% improvement margin in multi-hop tasks compared to the next best solution. Refiner is a plug-and-play solution that can be seamlessly integrated with RAG systems, facilitating its application across diverse open-source frameworks.

  • 6 authors
·
Jun 17, 2024

RefineRank: Joint Box Refinement and Ranking for Surgical Spatio-Temporal Grounding

Surgical spatio-temporal grounding (STG) requires locating, at each video time specified by a procedural question, the object that the question asks about. Existing approaches face a trade-off: vision language models understand the question context but produce imprecise coordinates, whereas open-set detectors provide localized candidate boxes whose confidence does not reflect which box answers the question. We introduce RefineRank, which closes this gap at the candidate-box level. A compact trainable module, RefineNet, combines the language and regional features of a frozen medical vision language model with the proposals of a frozen open-set detector: it predicts a bounded coordinate correction and a quality score for every candidate box, and a fixed decoding rule returns the original or refined box with the highest score. On the MedVidBench Official Rankings (Verified), RefineRank records 0.421 STG mIoU, the highest displayed STG score, while its global multi-metric rank is 11. In a controlled evaluation on separate training and evaluation videos, coordinate correction raises the candidate oracle upper bound from 0.6772 to 0.7302, and ranking the joint pool of original and refined candidates by their RefineNet scores improves STG mIoU from 0.2719 to 0.4534, whereas separately trained selectors over the same pool reach at most 0.4186. These results show that a small box-level module can reconcile question understanding with precise localization without retraining either backbone. Code is available at [https://github.com/linzhe001/RefineRank](https://github.com/linzhe001/RefineRank).

  • 6 authors
·
Aug 24